中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2012, Vol. 41 ›› Issue (4): 336–339.

• 临床医学 • 上一篇    下一篇

Lewis y抗原及胰岛素样生长因子受体1在卵巢浆液性肿瘤中的表达及临床意义

刘大我,刘娟娟,林蓓,胡珍华,高健,侯锐,刘川,郝莹莹,张淑兰   

  1. (中国医科大学附属盛京医院妇产科,沈阳 110004)
  • 收稿日期:2012-09-24 修回日期:2012-09-24 出版日期:2012-04-20 发布日期:2012-09-26

Expression and Clinical Significances of Lewis y Antigen and IGF-1R in Ovarian Serous Cystadenocarcinoma

LIU Da-wo, LIU Juan-juan, LIN Bei, HU Zhen-hua, GAO Jian, HOU Rui, LIU Chuan, HAO Ying-ying, ZHANG Shu-lan   

  1. (Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang 110004, China)
  • Received:2012-09-24 Revised:2012-09-24 Online:2012-04-20 Published:2012-09-26

摘要: 目的 探讨Lewis y抗原及胰岛素样生长因子受体1(IGF-1R)在卵巢浆液性肿瘤中的表达及意义。方法 采用免疫组化SP法检测卵巢黏液囊腺癌(恶性组)、交界性卵巢浆液性囊腺瘤(交界性组)、良性卵巢浆液性囊腺瘤(良性组)和正常卵巢组织(正常组)中Lewis y抗原与IGF-1R的表达。用免疫荧光双标记法检测二者在卵巢癌组织中表达的相关性。结果 恶性组中Lewis y抗原和IGF-1R的阳性率明显高于交界性组、良性组及正常组(P0.05);低分化组中IGF-1R的表达水平与中、高分化组相比,差异有统计学意义(P0.05),而低、中、高分化3组间Lewis y抗原表达差异无统计学意义(P0.05)。Lewis y和IGF-1R在恶性组中的表达水平增高,具有正相关性(P0.05),且二者存在共定位关系。结论 Lewis y抗原及IGF-1R参与了卵巢浆液性肿瘤由良性向恶性的转化与发展,与患者的预后密切相关。

关键词: 关键词 卵巢浆液性肿瘤, IGF-1R, Lewis y抗原, 免疫组织化学

Abstract: Abstract Objective To study the expression and the clinical significances between Lewis y antigen and insulin-like growth factor receptor 1 (IGF-1R) in ovarian serous tumors. Methods The S-P method was used to investigate the positive expression rates of Lewis y and IGF-1R in paraffin-embededembedded samples of malignant ovarian serous malignant tumors (malignant group), borderline ovarian serous cystadenoma (borderline group), and benign serous ovarian cystadenoma (benign group) and normal ovarian tissues (normal group). Double labeling immunofluorescence method was used to detect the expression of Lewis y and IGF-1R and their correlation was analyzedbetween Lewis y and IGF-1R. Results The positive rates of Lewis y antigen and IGF-1R in malignant tumors were evidently higher than those in borderline and benign tumors and normal tissues (P0.05). The expression intensity of IGF-1R in low differentiated tumors was higher than those in moderately and highly tumors (P0.05), but there is no statistical significance of Lewis y antigen expression in three differentiated all the tumors. Positive correlation and synchronization expression were found between Lewis y antigen and IGF-1R in ovarian serous tumor tissues. Conclusion Lewis y and IGF-1R participate in the procedure of malignant transformation of a benign tumor transformed to malignant, and strongly correlate with differentiation of ovarian cancer, which is expected to be the diagnostic- aid marker to aid the in early diagnosis of ovarian serous cystadenocarcinoma.

Key words: ovarian serous tumor, IGF-1R, Lewis y antigen, immunohistochemistry

中图分类号: 

  • R737. 31 文献标志码 A 文章编号
[1] Kin WY, Jin Q, Oh SH, et al. Elevated epithelial insulin-like growth factor expression is a risk factor for lung cancer development [J]. Cancer Res, 2009, 69(18) 7439-7448.
[2] Eckstein N, Servan K, Hildebrandt B, et al. Hyperactivation of the insulin-like growth factor receptor 1 signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells [J]. Cancer Res, 2009, 69(7) 2996-3003.
[3] Oh SH, Jin Q, Kim ES, et al. Insulin- like growth factor- I receptor signaling pathway induces resistance to the apoptotic activities of SCH66336 (lonafamib) through Akt mammalian target of rapamycin–mediated increases in sruvivin expression [J]. Clin Cancer Res, 2008, 14(5)1582-1589.
[4] Canonici A, Steelant W, Rigot V, et al. Insulin –like growth factor – I receptor, E – cadherin and alpha v integrin form a dynamic complex under the control of alpha- catenin [J]. Int J Cancer, 2008, 122(3)572-582.
[5] Yin BW, Finstad CL, Kitamura K, et al. Serological and immunochemical analysis of Lewis y (Ley) blood group antigen expression in epithelial ovarian cancer [J]. Int J Cancer, 1996, 65(4) 406-412.
[6] Gao LL, Yan LM, Lin B, et al. Enhancive effects of Lewis (y) antigen on CD44-mediated adhesion and spreading of human ovarian cancer cell line RMG-I [J]. J Exp Clin Cancer Res, 2011, 3015.
[7] Liu JJ, Lin B, Hao YY, et al. M. Lewis(y) antigen promotes the proliferation of ovarian carcinoma-derived RMG-I cell through the PI3KAkt signaling pathway [J]. J Exp Clin Cancer Res, 2009, 28154.
[8] Yan LM, Lin B, Zhu LC, et al. Enhancement of the adhesive and spreading potentials of ovarian carcinoma RMG-I cells due to increased expression of integrinα5β1 with the Lewis (y) structure on transfection of theα1,2- fucosyltransferase gene [J]. Biochimie, 2010, 92(7) 852-857.
[9] Carlberg M, Dricu A, Blegen H, et al. Mevalonic acid is limiting for N-linked glycosylation and translocation of the insulin-like growth factor-1 receptor to the cell surface. Evidence for a new link between 3-hydroxy-3-methylglutaryl-coenzyme a reductase and cell growth [J]. J Biol Chem, 1996, 271(29)17453-17462.
[10] Ouban A, Muraca P, Yeatman T, et al. Expression and distribution of insulin-like growth factor-1 receptor in human carcinomas [J]. Hum Pathol, 2003, 34(8)803-808.
[11] Baldus SE, Hanisch FG, Pütz C. Immunoreactivity of Lewis blood group and mucin peptide core antigens correlations with grade of dysplasia and malignant transformation in the colorectal adenoma-carcinoma sequence [J]. Histol Histopathol, 2002,17(1) 191–198.
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