中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2012, Vol. 41 ›› Issue (4): 347–350.

• 临床医学 • 上一篇    下一篇

COX-2 mRNA 在咽喉反流疾病中的表达

崔潇,王丽萍,周莹,孙士上,吕艳春   

  1. (中国医科大学附属盛京医院耳鼻咽喉科,辽宁 沈阳110004)
  • 收稿日期:2012-09-24 修回日期:2012-09-24 出版日期:2012-04-20 发布日期:2012-09-26
  • 基金资助:
    辽宁省自然基金 20092135

Expression of COX-2 mRNA in Laryngopharyngeal Reflux

CUI Xiao ,WANG Li-ping,ZHOU Ying, Sun Shi-shang ,Lv Yanchun   

  1. (Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, Shenyang 110004, China)Corresponding author: WANG Liping, Email: wanglp@sj-hospital.org
  • Received:2012-09-24 Revised:2012-09-24 Online:2012-04-20 Published:2012-09-26

摘要: :目的 探索环加氧酶-2(cyclooxygenase-2,COX-2)mRNA在咽喉反流(laryngopharyngeal reflux,LPR)疾病病变黏膜组织中的表达情况。方法 对临床30例患有声带病变并可疑有咽喉反流的患者行电子鼻咽喉镜及通过反流症状指数量表(the reflux symptom index, RSI)和反流检查计分量表(the reflux finding score, RFS)进行评分,根据评分划分实验1组(20例),实验2组(10例),取正常黏膜 (10例)作为对照组。于手术中取得组织标本,采用real time-PCR方法,测定各组粘膜中COX-2 mRNA的表达情况。结果 Real time-PCR结果显示:实验1组及实验2组的COX-2 mRNA表达均明显高于正常对照组,具有统计学差异(pP<0.01,pP<0.05);实验1组COX-2 mRNA 明显高于实验2组(pP<0.05)。结论 COX-2 mRNA在咽喉反流病变中黏膜中表达明显升高,表明COX-2参与咽喉反流疾病的发生发展过程,为进一步研究咽喉反流疾病的病理损伤机制、为寻找预防干预方法及药物治疗靶点提供基础。

关键词: 关键词:环加氧酶-2, 咽喉反流, 反流症状指数量表, 反流检查计分量表

Abstract: Abstract Objective To investigate COX-2 mRNA expression in mucous membrane of patients with laryngopharyngeal reflux (LPR) . Methods Thirty cases with vocal cord lesions and suspected with LPR were examined by electronic nasopharyngeal laryngoscope and scored by the reflux symptom (RSI) and the refluz finding score (RFS).

Key words: COX-2, laryngopharyngeal reflux(LPR), reflux symptom index(RSI), reflux finding score(RFS)

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