中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2012, Vol. 41 ›› Issue (5): 427–430.

• 基础医学 • 上一篇    下一篇

补肾祛瘀汤对子宫内膜异位症大鼠治疗的机制研究

于敏1,张宝文2,陈晓云2, 弓瑞飞3   

  1. 1.大连大学附属中山医院康复医学科,大连 116001;2.大连大学医学院中医中药学系,大连,116622;3. 山西孝义市人民医院中医科,山西 孝义,032300
  • 收稿日期:2012-09-27 修回日期:2012-09-27 出版日期:2012-05-20 发布日期:2012-09-27

Inhibitory Effects of Bushen Quyu Tang on Angiogenesis of Endometriosis in Rat Model of Endmetriosis and Its Mechanism

YU Min1,ZHANG Bao-wen2,CHEN Xiao-yun2,GONG Rui-fei3   

  1. 1. Department of Rehabilitation Medicine in Affiliated Zhongshan Hospital of Dalian University, Dalian 116622,China;2. Institute of Chinese Medicine, Dalian University, Dalian 116622, China;3. The Traditional Chinese Medicine Department in people's hospital of Xiaoyi City, Xiaoyi 032300,China
  • Received:2012-09-27 Revised:2012-09-27 Online:2012-05-20 Published:2012-09-27

摘要: 目的 研究补肾祛瘀汤对子宫内膜异位症(EMS)模型大鼠血管内皮生长因子(VEGF)及survivin蛋白的影响,探讨补肾祛瘀汤对EMS的疗效机制。方法 SD大鼠50只随机分为5组:正常组(A组)、模型组(B组)、补肾祛瘀汤组(C组)、孕三烯酮组(D组)、补肾祛瘀汤加孕三烯酮组(E组),除正常组外其余均采用大鼠子宫内膜组织自体移植手术建立子宫内膜异位症模型,灌胃给药28 d后检测各组大鼠血清中和子宫内膜移植物局部VEGF和survivin蛋白表达。结果 与模型组比较,各治疗组大鼠VEGF及Survivin蛋白含量降低,差异有统计学意义(P<0.05)。结论 补肾祛瘀汤对大鼠子宫内膜异位症具有治疗作用,其作用机制可能与抑制异位内膜的血管新生有关,中西医结合治疗子宫内膜异位症效果更佳。

关键词: 关键词 补肾祛瘀汤, 子宫内膜异位症, 血管内皮生长因子, Survivin蛋白, 大鼠

Abstract: Objective To observe the effects of Bushen Quyu Tang (BQT, kidney-tonifying, stasis-removing decoction) on vascular endothelial growth factor(VEGF) and survivin protein in the rat model of endmetriosis, and to explore its mechanism . Methods Fifty EMS model rats were randomly divided into 5 groups: normal control group, model control group, the western Gestrinone medicine control group, BQT group and integrated Gestrinone and BQT control group. Rat self-endometria transplantation was used to build the model in all groups except the normal group. After intragastric administration for 28 days, the expressions of VEGF and survivin protein in ectopic endometrium were detected. Results Compared with the model group, contents of VEGF and survivin protein in each treatment groups had been deflated significantly (P < 0.05) . Conclusion BQT has certain therapeutic effects on endometriosis of rats. Its underlying mechanism may be that BQT could restrain the angiogenesis of ectopic endometrium. Integrative Chinese and Western therapy has better curative effect on EMS.

Key words: bushen quyu tang, endmetriosis, vascular endothelial growth factor

中图分类号: 

  • R271.9
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