中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2012, Vol. 41 ›› Issue (5): 474–475.

• 临床医学 • 上一篇    下一篇

脑脊液IL-17和IL-23检测在诊断细菌性脑膜炎中的意义

卜跃华,解芳   

  1. 中国医科大学高等职业技术学院检验教研室 沈阳 110001
  • 收稿日期:2012-09-27 修回日期:2012-09-27 出版日期:2012-05-20 发布日期:2012-09-27

05Diagnostic value of IL-17 and IL-23 in cerebrospinal fluid in bacterial meningitis

BU Yue-hua,XIE Fang   

  1. High Vocational Technological College, China Medical University, Shenyang 110001, China
  • Received:2012-09-27 Revised:2012-09-27 Online:2012-05-20 Published:2012-09-27

摘要: 目的 探讨脑脊液IL-17和IL-23检测在细菌性脑膜炎中的诊断价值。方法 对64份脑脊液进行白细胞计数和IL-17、IL-23的检测。应用受试者工作特征曲线(ROC)对其诊断价值进行评价,并采用直线回归方法进行相关性分析。 结果 细菌性脑膜炎组脑脊液IL-17和IL-23水平明显高于病毒性脑膜炎组和对照组(P<0.01),病毒性脑膜炎组IL-17和IL-23水平高于对照组(P<0.01)。脑脊液IL-17与IL-23,IL-17与白细胞计数、IL-23与白细胞计数呈明显正相关,相关系数分别为0.4980,0.5551和0.5810。结论 脑脊液IL-17和IL-23的检测可以用于对细菌性脑膜炎的鉴别诊断。

关键词: IL-17, IL-23, 脑膜炎, 脑脊液

Abstract: Objective To study IL-17 and IL-23 in the differential diagnosis of bacterial and viral meningitis. Methods The levels of IL-17 and IL-23 in cerebrospinal fluid of 64 cases were measured by ELISA method. The optimal cut-offs of IL-17 and IL-23 were identified by using ROC curve. The correlation among IL-17, IL-23 and WBC count were evaluated using linear regression. Results The levels of IL-17 and IL-23 in cerebrospinal fluid were higher in bacterial meningitis than in viral meningitis and the control (P<0.01), and the levels of IL-17 and IL-23 were higher in viral meningitis than the control (P<0.01). The correlations of IL-17 and IL-23, IL-17 and WBC count,IL-23 and WBC count were 0.4980,0.5551 and 0.5810, respectively. Conclusion IL-17 and IL-23 in cerebrospinal fluid in the differential diagnosis of bacterial and other meningitis has clinical application value.

Key words: IL-17, IL-23, meningitis, cerebrospinal fluid

中图分类号: 

  • R446.14
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