中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2013, Vol. 42 ›› Issue (10): 882–884.

• 论著 • 上一篇    下一篇

3种根管消毒药物治疗慢性根尖周炎的临床效果比较

张凌,高景,仇丽鸿   

  1. 中国医科大学口腔医学院牙体牙髓科,沈阳 110002
  • 收稿日期:2013-07-24 修回日期:2013-11-26 出版日期:2013-10-18 发布日期:2013-11-26
  • 作者简介:张凌(1970-),女,副教授,博士.

Comparison of the Antimicrobial Activity of ApexCal, Vitapex and Calcium Hydroxide as Intracanal Medicament

ZHANG Ling, GAO Jing, QIU Li-hong   

  1. Department of Endodentics, School of Stomatology, China Medical University, Shenyang 110002, China
  • Received:2013-07-24 Revised:2013-11-26 Online:2013-10-18 Published:2013-11-26

摘要: 目的 探讨ApexCal、Vitapex和氢氧化钙3种药物作为根管消毒剂对感染根管内粪肠球菌的抑制作用及对慢性根尖周炎患者的临床疗效。方法 将慢性根尖周炎需行根管治疗的60例患者随机分为3组,常规清理扩大根管后,分别将ApexCal(A组)、Vitapex(B组)糊剂、氢氧化钙(C组)糊剂置于根管内,作为消毒剂暂封,分别测定其对粪肠球菌的抑菌效果,并对患者的临床疗效进行观察和比较。结果 3组封药后根管内菌量明显降低,与封药前比较差异有统计学意义(P<0.05)。A、B组封药后根管内细菌降低量较C组有统计学差异(P<0.05)。对慢性根尖周炎患者的临床疗效A、B组与C组之间具有显著差异(P<0.05)。结论 ApexCal、Vitapex可以作为有效的根管消毒剂,对慢性根尖周炎的治疗具有临床实用价值。

关键词: 慢性根尖周炎, 根管消毒药物, 粪肠球菌, 实时RT-PCR

Abstract: ObjectiveTo investigate the antibacterial efficacy of ApexCal, Vitapex, and Calcium Hydroxide in root canal against endodontic pathogens.MethodsA total of 60 patients with chronic apical periodontitis were randomly divided into 3 groups with 20 patients in each group. After regular root canal preparation, all root canals were sealed for 7 days with different root canal sealing methods using ApexCal, Vitapex, and Calcium hydroxide, respectively . Enterococcus faecalis was assessed by Real-time quantitative polymerase chain reaction before and after disinfection. The effects of root canal disinfection of 3 groups were recorded and analyzed.ResultsThe fungus quantity in root canal was obviously reduced after the drug sealing in all the 3 groups, and the differences were statistically significant (all P< 0.05). The groups of ApexCal, Vitapex performed significantly better than the Calcium hydroxide group against Enterococcus faecalis(P< 0.05), leading to the better clinical curative effects of patients with chronic periarthritis (P < 0.05).ConclusionThe results supported that ApexCal and Vitapex can be used as an effective root canal disinfectant.

Key words: root canal disinfection, chronic apical periodontitis, enterococcus faecalis, real time RT PCR

中图分类号: 

  • R781.05
[1] 李政权,李俊,高. 两种根管消毒药物体外抑菌作用的比较研究[J].口腔医学研究, 2010,26(3):419-423.
[2] 樊明文.牙体牙髓病学[M].北京:人民卫生出版社,2001 :173.
[3] 唐彧,朱亚琴,王海宁,等. 3种根管消毒药物治疗有瘘型慢性根尖周炎的临床效果比较[J]. 上海口腔医学,2010,19(3):236-239.
[4]孙莹莹,于静涛,刘杨,等. 不同消毒方法对感染根管内粪肠球菌抗菌性的研究现状[J].中国实用口腔科杂志, 2011,4(12):759-761.
[5] Machado de Oliveira JC, Gama TG, Siqueira JF Jr, et al. On the use of denaturing gradient gel electrophoresis approach for bacterial identification in endodontic infections [J]. Clin Oral Investig,2007, 11(2):127-132.
[6] Wang J, Jiang Y, Chen W, et al. Bacterial flora and extraradicular biofilm associated with the apical segment of teeth with post-treatment apical periodontitis[J]. J Endod,2012, 38(7):954-959.
[7] Chugal N, Wang JK, Wang R,et al. Molecular characterization of the microbial flora residing at the apical portion of infected root canals of human teeth[J]. J Endod,2011, 37(10):1359-1364.
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