中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2013, Vol. 42 ›› Issue (10): 907–910.

• 论著 • 上一篇    下一篇

血清Survivin在关节炎中的变化及其临床相关性的研究

蔡琳,王晓非,郭韵,张晓莉,蒋莉,赵海燕   

  1. 中国医科大学附属盛京医院风湿免疫科,沈阳 110004
  • 收稿日期:2013-05-21 修回日期:2013-11-26 出版日期:2013-10-18 发布日期:2013-11-26
  • 作者简介:蔡琳(1986-),女,硕士研究生.

Changes of Serum Survivin Levels in Arthritis and the Clinical Correlation

CAI Lin, WANG Xiao-fei, GUO Yun, ZHNAG Xiao-li, JIANG Li, ZHAO Hai-yan   

  1. Department of Rheumatology and Immunology, Shengjing Hospital, China Medical University, Shenyang 110004, China
  • Received:2013-05-21 Revised:2013-11-26 Online:2013-10-18 Published:2013-11-26

摘要: 目的 检测类风湿关节炎(RA)及骨关节炎(OA)患者血清中survivin水平,研究其在RA及OA中的变化及其临床相关性。方法 用酶联免疫吸附法(ELISA)检测114例RA患者,31例OA患者和30例健康对照者血清的survivin水平,并分析血清survivin水平与RA及OA各临床和实验室指标的相关性。结果 ⑴RA组患者血清survivin水平高于OA组和对照组(P<0.05);⑵RA患者活动期血清survivin水平与缓解期无统计学差异(P>0.05);⑶RA患者出现X线骨侵蚀血清survivin水平高于非骨侵蚀患者(P<0.01);RA非骨侵蚀患者血清survivin水平高于OA患者(P<0.05);RA骨侵蚀组的病程、类风湿因子(RF)水平及抗环瓜氨酸肽抗体(抗CCP抗体)高于非骨侵蚀组(P<0.05);非骨侵蚀组的病程、RF水平、抗CCP抗体、C反应蛋白及血沉高于OA组(P<0.05);⑷RA组患者血清survivin水平与病程、RF水平、抗CCP抗体、vdH-Sharp评分呈正相关(r分别为0.289、0.385、0.803、0.341,P均<0.01)。结论 RA患者survivin水平增高,并与骨侵蚀性相关,在提示RA患者的关节损伤持续发展风险方面具有一定意义。

关键词: 生存素, 关节炎, 类风湿, 骨关节炎, 细胞凋亡

Abstract: Objective To evaluate the serum level of survivin in patients with rheumatoid arthritis (RA) and osteoarthritis (OA), so as to analyze its changes and clinical correlation in RA and OA. Methods A total of 114 patients with RA, 31 patients with OA and 30 healthy controls were enrolled for the study. The serum levels of survivin were determined by enzyme-linked immuno sorbent assay (ELISA), and its correlation with clinical and immunological parameters in RA and OA was analyzed. Results ⑴ The serum levels of survivin in RA patients were higher than that in OA patients and healthy controls(P<0.05); There was no significant difference of the serum survivin level between OA patients and healthy controls (P>0.05); ⑵ No significant difference was found of the serum survivin level between active group and remission group (P>0.05); ⑶ The serum levels of survivin in RA patients with erosive joint disease were higher than that without erosive joint disease(P<0.01); The serum levels of survivin in RA patients with non-erosive joint disease were higher than that in OA patients(P<0.05), but no significant difference was observed comparing with the healthy controls(P>0.05); The duration, rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (anti-CCP) of RA patients with erosive joint disease were higher than these with non-erosive joint disease(P<0.05); The duration, RF, anti-CCP, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) of RA patients with non-erosive joint disease were higher than OA patients(P<0.05); ⑷ The serum levels of survivin in patients with RA were positive correlated with the duration of disease, RF, anti-CCP and vdH-Sharp score (r=0.289, P<0.01; r=0.385, P<0.01; r=0.803, P<0.01; r=0.341, P<0.01). Conclusion The serum level of survivin is significantly increased in patients with RA, which is correlated with bone erosion. RA patients with high level of survivin tend to have high risk in persistent joint damage and high disease activity. There is no significant difference of the serum survivin level in OA patients .

Key words: survivin, arthritis, rheumatoid, osteoarthritis, apoptosis

中图分类号: 

  • R593.22
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