中国医科大学学报

中国医科大学学报

中国医科大学学报 ›› 2013, Vol. 42 ›› Issue (8): 722–725.

• 论著 • 上一篇    下一篇

帕金森病相关性流涎的研究

刘立娇,罗晓光,任艳,娄凡,刘娜,张熙悫   

  1. 1.中国医科大学附属第一医院神经内科,沈阳110001
  • 出版日期:2013-08-18 发布日期:2013-11-26
  • 作者简介:刘立娇,(1986-),女,硕士

Salivation in Parkinson's Disease

LIU Li-jiao,LUO Xiao-guang,REN Yan,LOU Fan,LIU Na,ZHANG Xi-que   

  1. Department of Neurology,The First Hospital,China Medical University,Shenyang 110001
  • Online:2013-08-18 Published:2013-11-26

摘要: 目的 探讨帕金森病相关性流涎的机制及其临床特点。方法 对帕金森病组和对照组进行帕金森病统一评分量表 (UPDRS)、帕金森病唾液分泌临床分级(SCS-PD)、吞咽功能障碍问卷(SDQ)、口面失用和MMSE的问卷调查,并通过唾液腺 ECT进行唾液腺功能的定性及半定量分析。结果 帕金森病组(PD)患者存在唾液腺分泌降低,与对照组相比差异有统计学意 义(P<0.05);PD1组和PD2组相比流涎情况差异无统计学意义(P>0.05);帕金森病组SCS鄄PD 评分与SDQ、UPDRS鄄玉及 UPDRS鄄域评分呈正相关性(P<0.01),与性别,年龄,病程,职业,分期,认知功能,UPDRS-III、姿势及口面失用无显著的相关性 (P<0.05)。结论 帕金森病相关性流涎主要为吞咽功能障碍所致;帕金森病相关性流涎随吞咽功能障碍加重、UPDRS-I及 UPDRS-II评分增高而逐渐加重;与帕金森病的发病密切相关,且可能在清醒时及睡眠时均出现流涎。

关键词: 帕金森病, 流涎, 唾液腺显像

Abstract: Objective Salivation is one of the common clinical manifestations of non鄄motor symptoms in Parkinson忆s disease,but there were very few researches about the Parkinson忆s disease related salivation. This paper discusses the mechanism and clinical features of saliva原 tion in Parkinson忆s disease. Methods UPDRS,SCS鄄PD,SDQ,orofacial apraxia and MMSE are used in Parkinson忆s disease group and the control group,the salivary gland function is also evaluated through salivary gland imaging for qualitative and semi-quantitative analysis. Results Patients in Parkinson's disease group showed decreased salivary secretion compared with control group,and the difference was statistically significant(P<0.05). There was no significant difference between PD1 group and PD2 group in salivation situation(P>0.05);SCS- PD scores was positively correlated with the scores of SDQ,UPDRS-I and UPDRS-II(P<0.01),but no significant correlation was observed between SCS-PD scores and the scores of gender,age,duration,occupation,stage,cognitive function,UPDRS-III,posture and orofacial apraxia(P>0.05). Conclusion Salivation in Parkinson's disease is mainly due to swallowing dysfunction,and aggravated with the swallowing disorder. The higher score of UPDRS-I and UPDRS-II,the worsened salivation is. Salivation is closely related to the pathogenesis of Parkinson's disease,and it may occurs while both awake and asleep.

Key words: Parkinson's disease, salivation, salivary gland imaging

中图分类号: 

  • R742.5
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