中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2019, Vol. 48 ›› Issue (1): 7-11.doi: 10.12007/j.issn.0258-4646.2019.01.002

• 论著 • 上一篇    下一篇

TC1和β-连环蛋白在宫颈癌和癌前病变组织中表达的关系和意义

兰翀1, 聂小毳1, 史玉林1, 徐洪涛2   

  1. 1. 沈阳市妇婴医院妇科, 沈阳 110011;
    2. 中国医科大学基础医学院病理学教研室, 沈阳 110122
  • 收稿日期:2018-04-19 出版日期:2019-01-30 发布日期:2019-01-05
  • 通讯作者: 徐洪涛 E-mail:xuht@cmu.edu.cn
  • 作者简介:兰翀(1977-),女,副主任医师,硕士.
  • 基金资助:
    国家自然科学基金(81372497);辽宁省自然科学基金(20170540833)

Expression of TC1 and β-catenin in Cervical Carcinoma and Precancerous Lesions and Their Significance

LAN Chong1, NIE Xiaocui1, SHI Yulin1, XU Hongtao2   

  1. 1. Department of Gynecology, Shenyang Women and Children's Hospital, Shenyang 110011, China;
    2. Department of Pathology, College of Basic Medical Science, China Medical University, Shenyang 110122, China
  • Received:2018-04-19 Online:2019-01-30 Published:2019-01-05

摘要: 目的 探讨甲状腺癌相关因子1(TC1)和β-连环蛋白(β-catenin)在宫颈癌和癌前病变组织中表达的关系和意义。方法 采用免疫组化方法检测TC1和β-catenin在80例宫颈鳞癌、40例低级别鳞状上皮内病变(LSIL)、40例高级别鳞状上皮内病变(HSIL)和30例宫颈正常组织中的表达情况。结果 TC1在宫颈鳞癌中的表达率显著高于LSIL(P=0.002)和正常宫颈组织(P<0.001),而与HSIL组织相比无统计学差异(P=0.576);TC1的表达与宫颈鳞癌的低分化程度(P=0.005)和高分期(P=0.004)相关。β-catenin在宫颈鳞癌中的异常表达率显著高于LSIL(P<0.001)和正常宫颈组织(P<0.001),而与HSIL组织相比无统计学差异(P=0.907);β-catenin的表达与宫颈鳞癌的低分化程度(P=0.025)和高分期(P=0.001)相关。TC1在宫颈癌前病变(r=0.549,P<0.001)和宫颈鳞癌组织(r=0.249,P=0.008)中的表达均与β-catenin显著相关。结论 TC1和β-catenin在宫颈鳞癌和HSIL组织中的表达显著高于LSIL和正常宫颈组织。TC1在宫颈鳞癌中的表达与β-catenin的异常表达相关,并与宫颈鳞癌的低分化程度和高分期相关。

关键词: 甲状腺癌相关因子1, β-连环蛋白, 宫颈癌, 癌前病变

Abstract: Objective To investigate the expression of thyroid cancer-1 (TC1) and β-catenin in cervical carcinoma and precancerous lesions and their significance. Methods Immunohistochemical methods were used to examine the expression of TC1 and β-catenin in 80 cervical squamous cell carcinoma (CSCC) tissues,40 high-grade squamous intraepithelial lesions (HSIL),40 low-grade squamous intraepithelial lesions (LSIL),and 30 normal cervical tissues. Results Although TC1 expression in CSCC was significantly higher than that in LSIL (P=0.002) and normal cervical tissues (P<0.001),it was similar to that in HSIL (P=0.576). TC1 expression was positively correlated with poor differentiation (P=0.005) and advanced FIGO stage (P=0.004) in CSCC. β-catenin expression in CSCC was significantly higher than that in LSIL (P<0.001) and normal cervical tissues (P<0.001),but was similar to that in HSIL (P=0.907). The abnormal β-catenin expression was also correlated with poor differentiation (P=0.025) and advanced FIGO stage (P=0.001) in CSCC. TC1 expression was positively correlated with the abnormal β-catenin expression in CSCC (r=0.294,P=0.008) and cervical squamous intraepithelial lesions (r=0.549,P<0.001). Conclusion TC1 and β-catenin expression in CSCC and HSIL was significantly higher than that in LSIL and normal cervical tissues. TC1 expression correlated with the abnormal β-catenin expression,and with poor differentiation and advanced FIGO stage of CSCC.

Key words: thyroid cancer-1, β-catenin, cervical carcinoma, precancerous lesion

中图分类号: 

  • R737.33
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