中国医科大学学报

中国医科大学学报
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中国医科大学学报 ›› 2019, Vol. 48 ›› Issue (1): 75-77,84.doi: 10.12007/j.issn.0258-4646.2019.01.016

• 论著 • 上一篇    下一篇

中性粒细胞与淋巴细胞比值在Ⅱ、Ⅲ期中低位直肠癌评估中的临床价值

张海鑫, 苏琪   

  1. 中国医科大学附属盛京医院结直肠肛门外科, 沈阳 110004
  • 收稿日期:2017-10-23 出版日期:2019-01-30 发布日期:2019-01-05
  • 通讯作者: 苏琪 E-mail:suq@sj-hospital.com
  • 作者简介:张海鑫(1992-),男,硕士研究生.

Clinical Value of Neutrophil/Lymphocyte Ratio in StageⅡand Ⅲ Middle and Low Rectal Cancer

ZHANG Haixin, SU Qi   

  1. Colorectal Anus Surgical Ward, Shengjing Hospital, China Medical University, shenyang 110004, China
  • Received:2017-10-23 Online:2019-01-30 Published:2019-01-05

摘要: 目的 探讨中性粒细胞与淋巴细胞比值(NLR)在Ⅱ、Ⅲ期中低位直肠癌中的临床价值。方法 回顾性分析经手术切除治疗的111例Ⅱ、Ⅲ期中低位直肠癌患者的临床及病理资料。对不同临床因素及病理参数的NLR值进行统计学分析。根据术前患者的外周血NLR水平,将患者分为高NLR(≥ 1.99)组及低NLR(<1.99)组,并对2组临床、病理参数及无病生存期进行分析。结果 肿瘤最大直径与NLR值存在正相关性(P<0.05)。2组患者在年龄、Ⅱ和Ⅲ期分期、N分期、病理类型、肿瘤最大直径、无病生存时间等方面的差异有统计学意义(P<0.05)。结论 术前NLR值对Ⅱ、Ⅲ期中低位直肠癌病理参数有一定的预测价值,可能成为评估其预后的指标。

关键词: 中低位直肠癌, 中性粒细胞与淋巴细胞比值, 术前

Abstract: Objective To explore the clinical value of neutrophil/lymphocyte ratio (NLR) in staging of stage Ⅱ/Ⅲ middle and low rectal cancer. Methods The clinical and pathological data of 111 patients with middle and low rectal cancer who underwent surgical treatment were retrospectively analyzed. The NLR values along with various clinical factors and pathological parameters were also statistically analyzed,and then the relationship between preoperative NLR and various clinical factors was determined. All patients were divided into high and low groups based on NLR,with the cut-off value of 1.99. Then,the clinical,pathological parameters and disease-free survival of the two groups were analyzed. Results The maximum diameter of the tumor and the NLR value were positively correlated (P<0.05). The patients with high and low NLR had significant differences in age,stage Ⅱ and Ⅲ,N stage,pathological type,maximum diameter of the tumor,and disease-free survival (P<0.05). Conclusion Preoperative NLR values may be used as predictive values for the pathological parameters of stage Ⅱ and Ⅲ middle and low rectal cancer,and NLR may be an indicator of its prognostic assessment.

Key words: middle and low rectal cancer, neutrophile/lymphocyte ratio, preoperative

中图分类号: 

  • R735.3
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